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Methods Search strategy and selection criteria The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420251088025

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As a primary screening, genomic DNAs from the tail of the pups were subjected to genomic PCR to identify animals with the transgene using the three primer pairs covering different parts of the construct (pair A: pCAGGS_FW2 : 5TAACCATGTTCATGCCTTCT3 and Mpst_Rv1 : 5TTTACTGAGCCAGGGATGT3, pair B: Mpst_Fw1 : 5ATCTACGACGACAGTGACCA3and globinA_Rv1 : 5GTCGAGGGATCTCCATAAGA3, and pair C: CAG_Fw4 : 5ACCTGGGTCGACATTGATTA3 and CAG_Rv2 : 5AACATGGTTAGCAGAGGCTC3)

One report showed that neutrophils have minimal effects on BDL-induced liver fibrogenesis, as there is no significant difference in the production and deposition of collagen in the livers of anti-neutrophil antiserum treated mice or mice with neutrophil dysfunction due to transgenic expression of IL-8 (90)

elegans , indicating that oxidation of bacterial thiols is the major benefit of diamide (Supplementary Fig

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