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Interestingly, recent studies have shown that the specific deletion of Fbxw7 (a E3 ubiquitin ligase component) in Schwann cells is sufficient to induce the production of thicker myelin sheaths by these cells, together with a myelination of multiple axons similar to that observed with OLGs (Harty et al., 2019)

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Think of GSTs as redox rheostats, fine-tuning cellular balance in ways that help cancer cells survive under therapeutic stress

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The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation