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Laboratory studies demonstrated: Enhanced fatty acid oxidation in treated animal models Increased plasma glycerol release (an established index of active lipolysis) Elevated mitochondrial fatty acid oxidation capacity Both energy expenditure and fat oxidation increases even without classical -AR pathways The peptide appears to modulate metabolic flexibility in adipocytes

Validation of diacylglycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

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Copper is an essential trace element, but excess copper is toxic

therefore, the use of these agents should be discouraged (Smit et al., 2021)

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