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Also, the isotretinoin itself may initially flare the acne before it improves it
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"As a result of our investigation, we confirmed that the dataset in Figure 5 was indeed manipulated, and we proceeded with the retraction," the journal stated

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doi: 10.1089/ars.2011.4391 [DOI] [PMC free article] [PubMed] [Google Scholar] 52.Li FJ, Long HZ, Zhou ZW, Luo HY, Xu SG, Gao LC
