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This association is evidenced by elevated serum levels of pro-inflammatory cytokines, such as interleukin-1 (IL-1), tumor necrosis factor (TNF-), IL-6, and IL-17

redistribution resulting in tight junction and epithelial barrier repair

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Generally, increased free iron and lipid peroxidation are considered to be the two key components that contribute to oxidative damage to the lipid bilayer of the membrane in ferroptosis (Dixon et al., 2012)

These data hint at the therapeutic potential of targeting ferroptosis pathways in RM ( Research shows that cigarette smoke negatively affects placental development, compromises fetal health, and reduces maternal fertility, leading to outcomes such as spontaneous abortion