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Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols

In vitro , both CCK-8 assay and colony-formation assay showed that RRM2 overexpression significantly increased the proliferation rate and clone formation ability of TPC-1 cells, while knockdown of RRM2 significantly inhibited cell growth

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24 , 12281237 e1223 (2017)

Glutathione reductase (GR) can use NADPH to catalyze the reduction of oxidized glutathione (GSSG) to GSH, eliminating LPO on the cell membrane and preventing cell membrane damage, thereby inhibiting ferroptosis (Yang et al., 2014)