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Description
Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-B/iNOS signaling pathways

This antioxidant function protects cells from oxidative damage, supporting overall health

Many people struggle here due to low stomach acid, gastrointestinal conditions, certain medications, or age-related changes

2000;348(Pt 3):607614

This cascade enhances the L-type calcium current (I CaL ) and RyR2 activity, while suppressing the inward rectifier potassium current (I K1 ), leading to SR calcium leak and the eventual induction of DADs

Dai J, Gu J, Huang M, Eng C, Kopetz ES , Ellis LM, Hawk E, Wu X
