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The protein p53 encoded by this gene inhibits the development of tumors through the regulation of the cell cycle, apoptosis, genomic stability and other pathways

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TT genotype is associated with increased risk of: Colorectal and lung cancers Unipolar depression Adult acute lymphoblastic leukemia Ischemic stroke Cleft lip/palate Down syndrome (especially when combined with methionine synthase reductase mutations) Interestingly, the 677T allele may confer reduced susceptibility to hepatitis B virus (HBV) infection in endemic regions

Oxid Med Cell Longev 2020:1452696 Tonelli C, Chio IIC, Tuveson DA (2018) Transcriptional regulation by Nrf2