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Estrogen supplementation ameliorates pyroptosis and inflammation in Hcy-treated HUVECs (71), moreover, estradiol-17 can inhibit Hcy mediated damage by promoting H 2 S production via upregulating CBS and CSE expression in HUVECs ( via regulating PI3K/Akt/NOS pathway in vivo and in vitro (133)

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Both the obligately homofermentative and facultatively heterofermentative LAB dominate the sourdough microbiota when fermentation temperature is above 30 C, but when the sourdough starter is kept at temperature below 30 C, it comprises primarily obligately heterofermentative LAB [93]