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Silymarin ameliorates diethylnitrosamineinduced liver fibrosis in Wistar rats

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Then, 4.88 mL of simulated intestinal fluids containing 16 U/mL pancreatin (lot number SLCM8903, trypsin activity = 8.9 U/mg) and 3.1 mM bovine bile (lot number SLBV1780, bile salts concentration = 440 g/mol) were added

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However, upon exposure to powerful pro-oxidant stimuli such as dapsone or primaquine, acute extravascular and then intravascular hemolysis can occur leading to the release of heme and free iron into the local intravascular environment 57