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The approach to the diagnosis of CHS also requires a good clinical history and anatomic evaluations, with an upper gastrointestinal endoscopy and/or computed tomography scan of the abdomen to exclude outlet obstruction and other organic causes of vomiting

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However, cells are known to possess inherently poor antioxidant capacity (Lenzen et al., 1996), and this coupled with the lower levels of plasmalogens may result in enhanced susceptibility of cells to metabolic stress and ROS contributing to the autoimmune response