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TGF-1 induced EMT increases the intracellular levels of unstable iron and ROS, and the elevated iron content and oxidative stress in cells undergoing EMT make them more susceptible to ferroptosis

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[53] Vase tambin [editar] Referencias [editar] Nmero CAS [Merck Index], 11th Edition, 4369

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15LO1 increases intracellular oxidative potential by lowering GSH and increasing extracellular GSSG To confirm that 15LO1-PEBP1 complex activity alters IL-13induced intracellular GSH levels, we modeled these relationships in vitro by stimulating cultured HAECs (at ALI) with IL-13 for 710 days in the presence and absence of 15LO1 protein (dicer siRNA knockdown [KD] of ALOX15 gene) or enzymatic activity (specific 15LO1 inhibitor BLX2477) (14, 15)

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MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines

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