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Neil Rawlins says it may take some as many as 4 months (at a therapeutic dose - for some that is as much as 15 mg) to notice that they are actually feeling better
Mol Immunol 43:17291740 Gu X, Nylander E, Coates PJ et al (2015) Correlation between reversal of DNA methylation and clinical symptoms in psoriatic epidermis following narrow-band UVB phototherapy

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Abd-Rabou AA, Zoheir KMA, Kishta MS, Shalby AB, Ezzo MI

doi: 10.1016/j.freeradbiomed.2021.06.016

Fact: As we discussed, formulation matters
