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Compounds derived from garlic, such as diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), also demonstrate strong HDAC inhibitory properties

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These scaffolds demonstrated a significant increase in Youngs modulus when mineralized in situ with calcium superphosphate

Transitioning from these cellular findings to the robust identification of these circulating oxidized byproducts (such as 4-HNE, specific epoxy-derivatives, or altered ceramide ratios) in the bloodstream will solve two problems at once: providing a reliable, non-invasive tool to monitor FRDA progression and offering definitive proof of target engagement when testing new anti-ferroptotic drugs

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