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B12 after absorption in the bloodstream then binds to transcobalamin (TC) for systemic transport

The form and route both matter

However, increasing oral supplement doses (within safe limits) while awaiting medical review is generally considered safe, as B12 has very low toxicity and excess is excreted through the kidneys

Researchers should employ standard laboratory safety protocols including the use of gloves and eye protection when handling the product

This product may contain aluminum, which may accumulate to toxic levels in patients with renal dysfunction or during high-dose or long-term treatment

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