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Description
Activation of the POMC neurons has been demonstrated to initiate the production and release of -MSH from the POMC axon terminals [138,139]
The cumulative effect of all three peptides converges
NOXs (NOX15 and dual oxidases (DUOX) 1 and 2) catalyze the superoxide anions or H 2 O 2 from NADPH and oxygen
Consistent with the role as a second hit, MAPK are known to be activated by oxidative stress and have been involved in APAP hepatotoxicity
X-hJ: Conceptualization, Project administration, Writing original draft, Writing review & editing
A similar trend was observed for SAM and SAH
