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High levels of free radicals increase excitability of both central (brain and spinal) and peripheral nerves and reduce pain thresholds, potentially leading to chronic hypersensitization

Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain

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[1] Role in Treatment: ALC can be considered as first-line or adjunctive therapy for DPN

Muscle Preservation and Metabolic Stress Resistance L-Carnitine demonstrates significant muscle-protective properties through multiple mechanisms including prevention of protein degradation, reduction of inflammatory signaling, and maintenance of mitochondrial integrity during metabolic stress