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10.1016/S0031-9422(00)85377-7 Phytochemistry 52 FrovaC

6A), leading to the identification of two significantly upregulated hsa-miRNAs: hsa-miR-499a-5p and hsa-miR-127-5p (Fig

Although, compared to younger ages and nTg neurons, 3xTg-AD neurons cultured in vitro under constant and controlled conditions have a defined genotype with human APP (SWE), PS1 (M146V), and Tau (P301L) transgenes to mimic neuropathological features of familial AD, they are limited in application because of the relative overproduction of APP in this model