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These investigations aim to optimize the safety and effectiveness of chemoradiotherapy regimens while simultaneously reducing the associated side effects [522].Additionally, in silico and in vitro studies have provided evidence that EGCG targets NF- B pathway, highlighting its potential as a therapeutic alternative for pancreatic cancer treatment by reducing cell growth, inducing apoptosis, and repressing NF- B target genes [523]

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These studies indicate that reduction of apoCIII by antisense oligonucleotide inhibition significantly reduces circulating triglyceride levels (654,655)
