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The two latest meta-analyses do not prove the hypothesis that acetyl-l-carnitine exerts a positive effect on chemotherapy-induced polyneuropathy [69, 77], and its use is not recommended by the ASCO guidelines [76]

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doi: 10.1146/annurev-physiol-012110-142233 58 JinP.BianY.WangK.CongG.YanR.ShaY

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Acetyl-L- carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain Brain Res 1998

The addition of fumarateas seen in the specific compound L-carnitine fumarateprovides an extraordinary metabolic advantage