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Preparation of G/D-CuP 15% PVA-1788 (w/w) solution (1 mL), 12 mM D-CuP solution (650 L), and EBPBA solution (5 mg mL 1 , 350 L) were mixed thoroughly and stirred rapidly to obtain G/D-CuP

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Simultaneously, glutathione-S-transferase (GST) activity decreases by 72%, reducing the cellular capacity to clear toxic metabolites ( 3.3 Oxidative stress and mitochondrial dysfunction EED-induced oxidative stress represents a central mechanism underlying reproductive toxicity, with mitochondrial dysfunction serving as both cause and consequence of excessive reactive oxygen species production