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[4] By supplying additional NAD+ to the body, NAD+ Injection may help ensure these energy-producing pathways can proceed optimally, particularly in situations of NAD+ depletion

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The source of WS is the Werner (WRN) DNA helicase gene, which regulates the transcription of the essential NAD+ biosynthetic enzyme Nicotinamide Nucleotide Adenylyltransferase 1 (24,25). NAD+ depletion through disruption of mitochondrial homeostasis is a substantial contributor to the metabolic dysfunction in WS, according to a 2019 study (25)

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Levels should be in the normal or high-normal range if supplementation is adequate

Key finding: AOD 9604 increased bone formation rate by 67%, increased lumbar spine BMD by 12%, and increased trabecular density