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Consistent with this notion, our supplementary experiment using a stronger SDS paradigm (5-minute defeat episodes) revealed a stress-intensity-dependent exacerbation of anxiety-like behaviors: WT mice, which showed no anxiety phenotype under the milder SDS condition, developed clear anxiety-like responses when the stress load was increased, whereas KI mice displayed even more pronounced behavioral impairments

A single daily injection will not work

Non-invasive: No needles or clinical appointments required

Overall preclinical safety profile has not raised major flags at tested doses

Remarkably, this specific sequence is considered to be essential and fully responsible for biological activities of the compound [30]

Anti-Inflammatory & Antioxidant Effects: GHK-Cu lowers inflammatory cytokines and boosts antioxidant enzyme activity (e.g., superoxide dismutase), helping protect cells from oxidative damage and chronic inflammation both of which are key factors in aging and tissue degeneration