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Quercetin also showed elevated accumulation with time and concentration in rat brain endothelial cells [282]
Some naturally occurring antioxidants as sulforaphane are potent inducers of this pathway ( In the brain, neuronal redox homeostasis is greatly dependent on astrocytic production of GSH ( These changes in astrocytic activity could be initiated by direct changes in redox balance
Intracellular concentrations of 4HNE may be critical for cells 13
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