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Persistent elevation on repeat testing, particularly with unexplained symptoms such as weight loss or fatigue, warrants GP evaluation and systematic investigation including full blood count and liver function tests

J Immunother Cancer 10(3):e004031 Nie Y et al (2020) Metal organic framework coated MnO2 nanosheets delivering doxorubicin and self-activated DNAzyme for chemo-gene combinatorial treatment of cancer

I also recommend regular monitoring of homocysteine, for the reasons already mentioned

[83] Brensocatib (Brinsupri) was approved for medical use in the United States in August 2025

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