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Description
Neurons and glial cells operate in a constant state of managing oxidative products, therefore making the CNS inherently vulnerable to redox dysregulation

Cancer 9 , 489499 (2009)

In the early twentieth century, neurologist Stern and his team, investigating substance transportation between the brain, cerebrospinal fluid, and peripheral blood, identified a semipermeable barrier separating the brain from the rest of the body, facilitating bidirectional movement, and named it the bloodbrain barrier

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Topical calcineurin inhibitors (TCIs) Non-steroidal topical calcineurin inhibitors (TCIs), including tacrolimus and pimecrolimus, have been found to be beneficial in the treatment of acute flares and maintenance therapy for AD in both adults and children over the age of two years