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Macrophage studies demonstrate that GHK-Cu administration shifts these cells from a pro-inflammatory M1 phenotype to a tissue-repairing M2 phenotype, increasing their production of growth factors including vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) by 40-60%

209 In contrast, human head and neck squamous cell carcinomas (HNSCCs) show loss of SMAD4 at an early-stage, and mice with Smad4 deletion develop spontaneous HNSCCs and genomic instability, suggesting that loss of SMAD4 is a tumor-initiating event in this context

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Bioavailability refers to the amount of a nutrient that actually makes it into your bloodstream and is available for your cells to use