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32,33,35 The lack of accumulation of intermediary metabolites suggests that the defect is located in the initial step of methionine transformation regulated by SAM synthe-tase

293 Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase in the TLR-mediated pathway, and inhibition of IRAK1/4 can block the TLR4/NF-B pathway and reduce intestinal inflammation

Data availability Raw RNA sequencing reads (fastq), count data, and metadata files have been deposited at the National Center for Biotechnology Information (NCBI) under Bioproject ID PRJNA1109844 with sequence read archive (SRA) accession numbers SRR28980933-SRR28980938

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Bone health is a critical consideration, particularly when combining caloric restriction with menopause