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Clinical studies indicate that nicotine NRT may reduce motor symptoms such as tremors, rigidity, and bradykinesia (Quik et al., 2015)

Transgenic mice overexpressing IGF-1 in osteoblasts exhibit a fivefold increase in periosteal bone formation in response to low magnitude loading
This, in turn, inhibits NLRP3 inflammasome activation through an ARRB2-dependent mechanism [40,41,42]

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