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Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib

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Recent studies have demonstrated that spermidine effectively inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1) by upregulating protein tyrosine phosphatase non-receptor 2 (PTPN2), thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and suppressing excessive inflammatory responses

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The inability to consume pyruvate alternatively results in its reduction to lactate, causing lactic acidosis (Rodrigues et al., 2018

Thus, a diagnosis requires a combination of clinical suspicion, specific abdominal ultrasound findings, and elevated feline pancreatic lipase immunoreactivity (fPLI) or DGGR lipase test results