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For instance, viral-mediated overexpression of BDNF in the PFC protects from stress-induced synaptic deficiencies by sustaining dendritic spine density and cognitive flexibility [267]

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/ -TrCP axis

Sekhar KR, Long M, Long J, Xu ZQ, Summar ML, Freeman ML

The body converts carnitine into other chemicals such as acetyl-carnitine and propionyl-carnitine

G.RojasC.TanegaC.ShenM.SimeonovA.BoxerM

More recent studies have demonstrated that, in addition to patients with germline mutations, those harboring de novo somatic mutations of BRCA1/2 and PALB2 also show benefit from PARP inhibitors, provided there is bi-allelic loss and established homologous repair deficiency in the tumors 89