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Research demonstrates that copper-binding peptides including GHK-Cu suppress the NF-B pathway through direct molecular interactions, with nuclear translocation of NF-B p65 decreased by approximately 30% upon treatment and molecular modeling showing specific peptide sequences exhibit high binding affinity to NF-B p65 (up to -8.8 kcal/mol)

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Furthermore, the definition of COPD exacerbation was also inconsistent between the studies included in this meta-analysis [103]

doi: 10.3389/fpls.2015.00655 [DOI] [PMC free article] [PubMed] [Google Scholar] 143.Di Sotto A, Gull M, Percaccio E, et al

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Furthermore, these pathological states can be examined in the context of chronic oxidative stress and quasi-stationary ROS levels (Lushchak 2014