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Alveolar macrophages derived from circulating monocytes recruited into the lungs by monocyte chemotactic factors produced by lung cells are increased 20-fold in COPD patients and release ROS as superoxide anions and hydrogen peroxide (102)

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This microneedle technology has effectively addressed the challenges in designing a triple-vessel liver chip with a dual-blood donor structure, providing a blueprint for the future construction of more sophisticated liver models [183]

However, other neurotransmitters and receptor systems are also involved (e.g., -aminobutyric acid (GABA) and serotonin) [97,98]

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