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Based on the genotype of MTHFR C677T, the serum level of total homocysteine, vitamin B12, folate, and red blood cell folate, there were significant differences in tHcy concentration between individuals with the TT genotype and those with the CC or CT genotype ( p 12 l mol/L) [73]

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We found that a transient overexpression of PPAR in HepG2 cells treated with NaOX reversed the suppression of the PPAR target genes, CPT1A and ACADM , compared with GFP control (Fig