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The finely tuned regulation of adrenal hormones can be disrupted by oxidative stress, which is caused by an imbalance between reactive oxygen species and the bodys antioxidant defense mechanisms (2)

14,15 Altered neurotransmitter functioning and possible neuroplasticity has been suggested to lead to the augmented sensory processing by the CNS

This intentional approach was chosen to embrace diverse, relevant research across different timeframes and to include immunomodulatory interventions that, primarily due to cost and other ethical constraints, have not yet been translated into clinical research

10.1186/s13041-019-0501-0 Mol

Long-term sleep deprivation will eventually lead to illness and other diseases

The model portrayed is for illustrative purposes only