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10.1113/expphysiol.1997.sp004024

Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling

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The findings indicated that silymarin significantly lowered AST and ALT levels in patients suffering from NAFLD and viral hepatitis, while its hepatoprotective effects were not significant in cases of drug-induced liver injury

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The concerns are formulation-level: copper ions can potentially destabilize some retinoid formulations, and layering both in one application step can increase irritation risk in sensitive users