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So the technology, we just follow the signs

132 , e142137 (2022)
The observation that replacement of the N-terminal norleucine with GABA yielded a compound with superior antidementia activity indicated that an N-terminal -amino group was not required for activity

That would be relatively inefficient, so NR seemed like the superior choice

The degree of structural damage present initially may influence durability of response

[DOI] [PubMed] [Google Scholar] Bartoli C.G., Tambussi E.A., Diego F., Foyer C.H