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428 Collins

Under physiological baseline conditions, the renal clearance of Lcarnitine is 13 mL/minute but increases to 78 mL/min following a 2g IV bolus dose and 100 mL/min after a 6g IV dose

doi: 10.1038/ejhg.2011.113

Reuben lived his entire life in the Charlottesville area
Biochem J 340: 255264

MC-4R-deficient subjects tended to prefer fatty foods and consume up to 95% more of them than control subjects [2]