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ABBREVIATIONS AcBut 4-(4-acetylphenoxy)butanoic acid ADC Antibody-drug conjugate ALL Acute lymphoblastic leukemia AML Acute myeloid leukemia BTG Bacterial transglutaminase CLL Chronic lymphocytic leukemia CM Cyclization module CRC Colorectal cancer DAR Drug-antibody ratio DLBCL Diffuse large B-cell lymphoma DM1 N 2 -Deacetyl-N 2 -(3-mercapto-1-oxopropyl)maytansine DM4 N 2 -Deacetyl-N 2 -(4-mercapto-4-methyl-1-oxopentyl)maytansine DUBA Duocarmycin hydroxybenzamide azaindole FGE Formylglycine generating enzyme mc Maleimidocaproyl mcc Maleimidomethyl cyclohexane-1-carboxylate, linked to cysteine of mAb MCC Maleimidomethyl cyclohexane-1-carboxylate, linked to thiol of cytotoxin MDR Multidrug resistance MM Multiple myeloma MMAE Monomethyl auristatin E MMAF Monomethyl auristatin F NHL Non-Hodgkin lymphoma NHS N-hydroxy succinimide nnAA Non-natural amino acid NSCLC Non small-cell lung carcinoma PABC Para-aminobenzyloxycarbonyl PBD Pyrrolo[2,1-c][1,4]benzodiazepine RCC Renal cell carcinoma SC Squamous cell SCCHN Squamous cell carcinoma of the head and neck SPDB N-succinimidyl-4-(2-pyridyldithio)butanoate sulfo-SPDB N-succinimidyl-4-(2-pyridyldithio)-2-sulfo butanoate va Valine-alanine vc Valine-citrulline References 1.Schwartz RS