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Poststroke patients and patients with atrial fibrillation are commonly treated with both antihypertensive and anticoagulation drugs

Notably, the review highlighted that systemic administration (intraperitoneal in rodent models) produced effects comparable to local administration, suggesting the peptides effects are not purely local but involve systemic signalling pathways

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When administered following clinical assessment and appropriate dosing, IV zinc is generally well tolerated

This means a vial reconstituted for the 2mg phase (which provides 5 weekly doses from a 10mg vial) should be used within about 5 weeks, which aligns perfectly with the 4-week dose escalation schedule plus a small buffer