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Further evidence for this hypothesis comes from recent yeast two-hybrid studies performed with enzymes from sweet peony, where the arGST Ps GSTF3 was found to interact with Ps DFR, the dihydroflavonol reductase catalysing the formation of 3,4- cis -leucocyanidin ( 6 ) 47

however, there may be a relative deficiency in GHRH and ghrelin secretion, and an increase in somatostatin secretion, in older individuals (18)