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Collectively, we speculate that the mode of action of PZQ involves multiple protein targets including SmTRPM PZQ and VGCCs, as part of a complex pathway resulting in disruption of S

TRX2 , besides to be required to regulate redox state and levels of glutathione in response to oxidants, it can be also up-regulated in response to changing growth conditions, providing a first line of defense against oxidative stress ( S

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We also are proposing that if more recent data subsequently become available (for example, a more recent estimate of the market basket update), we would use such data, if appropriate, to determine the FY 2024 market basket update in the final rule

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