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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771

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As soon as the effect of these substances wears off, the body begins to gradually return to its normal []

This suggestion was further insisted as a potential mechanism of TB-500 by the authors of the research study, who also commented that "transfection of anti-miR-146a nucleotides reversed the inhibitory effect of T4 on IRAK1 and TRAF6." Thus, TB-500 also appears to potentially work for healing by exerting anti-inflammatory action.(6)