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Cholesterol metabolism significantly contributes to cancer progression

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Kale RA, Gupta RK, Saraswat VA, Hasan KM, Trivedi R, Mishra AM, et al

For instance, glycyrrhizic acid is a representative triterpenoid saponin enriched in Glycyrrhiza glabra, whose major metabolite, glycyrrhetinic acid, was reported to exhibit rapid anti- H

3 examd

However, in cancer cells, dysregulation of the PI3K/AKT/mTOR pathway drives reprogramming of lipid metabolism, which is manifested by abnormal enhancement of FAO, which not only provides ATP for tumors, but also inhibits apoptosis and regulates redox homeostasis, which ultimately leads to the development of tumor drug resistance [36, 188, 189]