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Although immunogenicity to biologics is often not directly associated with adverse events in animal models, these studies have limited predictive power for the immunogenicity of the biologic in humans

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CRTH2, an orphan receptor of Thelper2cells, is expressed on basophils and eosinophils and responds to mast cellderived factor (s)

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This represents an important challenge in research as current assays and cell-based systems are not able to capture dynamic bias and will only offer information on the system at one given time-point