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Oxidative stress inducers, such as oxidizing agents and electrophilic chemicals, cause KEAP1 oxidation, which inhibits NRF2 degradation by the KEAP1-Cullin3 ubiquitin ligase complex
Yuen et al,2022)
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The 5-year relapse-free rate was 98% in patients with grade 1 tumors in whom both dense adherence and large-volume ascites were absent
