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According to the National Research Council (NRC), the daily recommended allowance of cobalamin for an adult dog weighing 33 pounds consuming 1,000 calories per day is 9 mcg

In contrast, the 2,3-diamino substitution in the 1MQ scaffold (2,3-diamino-1MQ) displayed high passive permeability (Table 1), but moderate bi-directional active transport with moderate efflux ratio (Table 2)