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Cognitive impairment can severely affect patients' quality of life and is also a significant factor contributing to increased mortality in PD patients [133]
A high frequency of diabetes is observed in patients with Friedreichs Ataxia (20-50%) and iron overload disorders such as hereditary hemochromatosis (3060%), phenotypes related to both insulin resistance and destruction of pancreatic -cells
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Norepinephrine activates the Raf-1 kinase / MAP kinase cascade through 1- and -adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy
10.3390/ijms22084220 3 BaeS
Carboxitin inhibited erythrulose-mediated mouse lens protein crosslinking, AGE formation and the formation of 3-deoxythreosone, a major ascorbate-derived AGE precursor in the human lens
