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In doing so, astrocytes dynamically modulate their interactions with neurons and synapses, with other glial cells, and with the vascular network that supplies nutrients to neurons, synapses and glia, while also regulating local blood flow 15,47,48

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Gastrointestinal side effects are common with retatrutide and include nausea, vomiting, diarrhoea, and reduced appetite

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The role and impact of ROS in metastasis, determining whether they facilitate or hinder this process, depend upon the type of tumor, the type of ROS species, the site of ROS generation within the tumor, the level of ROS, the difference between the antioxidant and prooxidant response, and other factors (Aggarwal et al

Also, because checkerboard-derived FICIs can vary with method (inoculum, endpoint, extract standardization) and may not fully predict in vivo interactions, we recommend completing FICI calculations by retrieving partner-MICs (or performing two-dimensional checkerboards) and confirming promising combinations with time-kill studies or PK/PD modeling prior to claiming clinical-relevant synergy (Bentley, 2024)