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In this study, the reaction volume was increased to 5 mL from the 100 L used in our previous study at 100 mM GSH to confirm the feasibility of large-scale production using simple 1,000-mL rection systems, for example

Leskiewicz M., Regulska M., Budziszewska B., Jantas D., Jaworska-Feil L., Basta-Kaim A., Lason W

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However, several factors support its safety profile

Chun S, An J, Kim MS

Metformin upregulates mitophagy in patients with T2DM: a randomized placebo-controlled study
